CAIS four-risk framework + where practitioners pull the lever 1. malicious use bad actor uses AI for harm bioweapons synthesis · disinformation · cyberattacks mitigations: • hardcoded prohibitions (L17) · Llama Guard (L18) • tool allowlist (L10, L11) 2. AI races competitive pressure overrides safety labs · companies · nations mitigations: • scaling policy with Risk Reports (L19, L20) • external evaluation (L21) 3. organizational risks (practitioners pull this) internal lab dynamics safety culture · audit · defenses · infosec mitigations: • escalation paths without career cost • independent audit, multi-layered defenses 4. rogue AIs capable AI pursuing misaligned goals grows with autonomy horizon (L1, L21) mitigations: • kill switches + canaries (L14) • propose-then-commit (L15) · checkpoints (L16) the three entities to know CAIS (non-profit, San Francisco, 2022) — four-risk framework; 2023 extinction statement CAISI (NIST center, US government) — voluntary agreements; unclassified capability evaluations California SB-53 — first US state-level catastrophic-risk regulation if signed